Immunotherapy with
NK cells
Targeted cell therapy for the elimination of tumor and virus-infected cells
It is the set of strategies used to stimulate and reactivate the immune system with the aim of controlling and combating oncological and viral processes, among others.
Its main advantage lies in the absence of side effects caused by conventional therapies such as radiotherapy and chemotherapy.
Its two main pillars involve the reactivation of the immune system
through
- The use of external biological components
- As well as the extraction of immune system cells for their expansion and activation
in the laboratory
What are NK cells?
They are part of the innate immune system with a similar origin to T and B lymphocytes.
- They are defined as the first line of defense against viral diseases and oncological processes.
- They are widely studied and used in various tumor processes, with a higher rate of effectiveness in non-solid tumors, compared to solid ones
How do they work?
Being part of the innate immune system, it does not require prior exposure. Unlike T and B lymphocytes.
They employ two main mechanisms to exert their cytotoxic function (cell elimination)
- Direct mechanism: By releasing substances that create holes on the surface of the target cell (Granzymes and Perforins)
- Indirect mechanism: It involves sending signals through its surface molecules that force the target cell to enter into cell death processes (FAS and TRAIL death receptors).
They have been applied safely and with positive effects in almost all types of tumors.
Current clinical trials report a success rate of over 80%, compared to groups where patients received only conventional therapy.
La efectividad del tratamiento, dependerá de tres puntos esenciales:
- Type of tumor
- Tumor stage and
- General health status of the patient
Reported pathologies
- Acute Myeloid Leukemia
- Chronic Myeloid Leukemia
- Multiple Myeloma
- Myelodysplastic Syndrome
- B-cell Acute Lymphoblastic LeukemiaChronic Lymphocytic Leukemia
- Non-Hodgkin Lymphoma
- Hodgkin Lymphoma
- B-cell Lymphoma
- Prostate cancer
- Ovarian cancer
- Non-small cell lung cancer
- Glioblastoma
- Head and neck cancer
- Melanoma
- Liver cancer
- Colorectal cancer
- Renal cell cancer
- Breast cancer
- Neuroblastoma
- Biliary tract cancer
- Pancreatic cancer
Immunotherapy is personalized according to the patient’s characteristics and pathology.
