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Mesenchymal Stem Cell Therapy in Osteoarthritis Management
Mesenchymal stem cell (MSC) therapy is being explored as a potential treatment for osteoarthritis (OA), a degenerative joint disease characterized by the breakdown of cartilage and underlying bone changes. MSCs are a type of adult stem cell found in various tissues, such as bone marrow, adipose (fat) tissue, and umbilical cord blood. They possess the ability to differentiate into multiple cell types, including chondrocytes (cartilage cells), osteoblasts (bone-forming cells), and adipocytes (fat cells).
Here’s how mesenchymal stem cells may help in osteoarthritis:
- Cartilage Repair: One of the primary roles of MSCs in osteoarthritis is their potential to differentiate into chondrocytes, the cells responsible for producing and maintaining cartilage. Injecting MSCs into the affected joint may stimulate the repair of damaged cartilage, slowing down the progression of OA and potentially improving joint function.
- Anti-inflammatory Properties: MSCs possess potent anti-inflammatory properties. Inflammation plays a significant role in the progression of osteoarthritis, contributing to pain and tissue damage. MSCs can modulate the immune response and reduce inflammation in the joint environment, providing relief from symptoms associated with OA.
- Promotion of Tissue Regeneration: Apart from their ability to differentiate into chondrocytes, MSCs can also release various growth factors and cytokines that promote tissue regeneration and repair. These factors stimulate the proliferation of existing chondrocytes and enhance the production of extracellular matrix components, such as collagen and proteoglycans, which are essential for maintaining cartilage structure and function.
- Modulation of Pain: Osteoarthritis is often associated with chronic pain, which significantly impacts the quality of life of affected individuals. MSCs have been shown to release factors that modulate pain perception, potentially providing pain relief in osteoarthritic joints.
- Immunomodulation: In addition to their anti-inflammatory effects, MSCs can modulate the immune response in the joint environment. This immunomodulatory capacity can help prevent further damage to the joint caused by inflammatory processes and autoimmune reactions.
Clinical studies and trials are ongoing to evaluate the safety and efficacy of mesenchymal stem cell therapy for osteoarthritis. While preliminary results are promising, further research is needed to optimize treatment protocols, determine the most suitable cell sources, and assess long-term outcomes. Additionally, challenges such as cell survival, homing to the target site, and potential adverse effects need to be addressed to harness the full therapeutic potential of MSCs in treating osteoarthritis.
Dosage for Osteoarthritis
-Intra-articular Application-
- 10 million mesenchymal stem cells
- 25 million mesenchymal stem cells
(Placed by a trauma doctor in the affected joint shoulder, knee, elbow, phalanges of hands or feet) extra cost for specialist doctor fees.)
1 application per month for 4 months
-Intravenous Application-
- 25 million mesenchymal stem cells
- 50 million mesenchymal stem cells
- 100 million mesenchymal stem cells
Recomended dose will be determinated at Drs first evaluation visit.
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